Preheat oven to 400f degrees. Spray a 10-inch cast iron skillet with Crisco no stick cooking spray.
In a bowl, whisk together cornbread mix with water. Stir in ¼ cup shredded cheese and Italian seasoning.
Pour mixture into skillet and bake for 10 minutes.
Meanwhile, in a large skillet over medium heat, brown and crumble ground beef along with onion and pepper. Season with salt and pepper. Drain excess grease and put back into the pan. Stir in pizza sauce.
Once cornbread has finished baking, spread beef mixture on top in an even layer.
Sprinkle with remaining cheese and top with pepperoni slices.
Place back in oven and bake for 10 minutes until cheese is melted.
Slice it into wedges and serve! This is easiest to eat with a fork. :)