Preheat oven to 350 degrees. Spray loaf baking dish with nonstick cooking spray (on bottom and sides).
In a bowl beat the egg and add the pumpkin puree, 1/2 cup sugar, and vanilla extract.
In a separate bowl mix the remaining sugar and pumpkin pie spice.
Separate the biscuits in half (lengthwise) and coat with the sugar mixture (coating all sides).
Spread the pumpkin mixture on each slice of the biscuits and stack in the bread pad carefully.
Bake in the oven for 40-45 minutes or until golden brown. Allow bread to cool completely.
Once bread is cool, make the glaze. Mix the cream cheese and powdered sugar with a hand mixer until smooth. Add two tablespoons of milk and mix again. If too thick, add milk a little at a time until you can drizzle the glaze. Using a spoon, drizzle the icing over the pumpkin bread.