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5 from 2 votes


Bisquick Chicken Enchilada Bake is a delicious casserole made with rotisserie chicken, taco seasoning, enchilada sauce and mozzarella cheese.
Prep Time10 mins
Cook Time30 mins
Total Time40 mins
Course: Main Course
Cuisine: American
Keyword: Bisquick Chicken Enchilada Bake
Servings: 6
Calories: 399kcal
Author: Brandie @ The Country Cook


  • 2 cups Original Bisquick mix
  • 1 cup water
  • 1 (10 oz) can mild green chile enchilada sauce
  • 1 (10.75 oz) can cream of chicken soup
  • 2 tbsp taco seasoning
  • 2 cups diced, cooked chicken
  • 2 cups shredded monterey jack cheese divided use


  • Preheat oven to 375F degrees.
  • Spray a 9 x 13 baking dish with nonstick cooking spray.
  • In a medium bowl, combine Bisquick mix with water.
  • Stir well (batter will be lumpy.)
  • Pour into baking dish and spread out evenly.
  • Using the same bowl (so as not to make any more dirty dishes than is necessary), combine enchilada sauce, cream of chicken soup, diced chicken, taco seasoning and 1 cup shredded cheese.
  • Combine well then evenly spread over the Bisquick layer.
  • Top with remaining shredded cheese.
  • Bake uncovered for 30 minutes, until bubbly and golden around the edges.


Allow to cool for several minutes, then slice and serve by itself or with shredded lettuce, diced tomatoes and sour cream.


Calories: 399kcal | Carbohydrates: 30g | Protein: 20g | Fat: 21g | Saturated Fat: 9g | Cholesterol: 58mg | Sodium: 1639mg | Potassium: 120mg | Fiber: 1g | Sugar: 5g | Vitamin A: 465IU | Vitamin C: 0.4mg | Calcium: 360mg | Iron: 2.2mg